“Pandemic fatigue” has set in across parts of Europe where the outbreak is on the rise again in some countries that were hailed early on for stamping out massive outbreaks.

France and Spain are now seeing more new cases every day than they did when the virus originally peaked in the spring. Israel on Friday entered a second nationwide lockdown, shuttering restaurants, hotels, gyms and more, amid soaring new cases and as the Jewish High Holiday season begins. While epidemiologists expected autumn to be worse, the rapid resurgence comes ahead of the official start of fall on Tuesday.

“There are some worrying trends that we’re starting to see,” Dr. Maria Van Kerkhove, head of the World Health Organization’s emerging diseases and zoonosis unit, said Wednesday. “What is really worrying I think for us is that we’re not only seeing an increase in the case numbers, but we’re seeing an increase in the hospitalizations. We’re seeing increases in ICUs.”

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